Before railroads and highways were developed, the Rhone was an important inland trade and transportation route, connecting the cities of Arles, Avignon, Valence, Vienne and Lyon to the Mediterranean ports of Fos, Marseille and Sète. Travelling down the Rhone by barge would take three weeks. By motorized vessel, the trip now takes only three days. The Rhône is classified as a class V waterway from the mouth of the Saône river to the sea.
In French, the adjective derived from the river is rhodanien, which is the name of the long, straight Saône and Rhone river valleys, a deep cleft running due south to the Mediterranean and separating the Alps from the Massif Central.