During his work as a doctor in Amsterdam , Sarphati encountered the bad hygiene among the poor in Amsterdam. His compassion for his patient led him to initiate several projects to improve the quality of life in the city and the health of its inhabitants. This included a bread factory producing wholesome, affordable bread, and a refuse collection service. Sarphati played an important role in the initiation of waste transport in 1847. He became involved in politics, particularly as a project developer in city planning. Beside public health, he initiated improvements in education and industrialization. After his death, Sarphatipark in Amsterdam was designed and named after him in 1885.
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